The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
Product Name:
Human TLK1/PKU-beta Recombinant Protein (RPES0925)
Product Code:
RPES0925
Size:
50 µg
Species:
Human
Expressed Host:
Baculovirus-Insect Cells
Synonyms:
KIAA0137,PKU-beta
Accession:
Q9UKI8-1
Sequence:
Met 1-Tyr 766
Fusion tag:
N-His & GST
Activity:
The specific activity was determined to be 1.6 nmol/min/mg using Histone H3 protein as substrate.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human TLK1 isoform 1 (Q9UKI8-1) (Met 1-Tyr 766) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
