NKG2D ligand 2; also known as N2DL-2; NKG2DL2; ALCAN-alpha; Retinoic acid early transcript 1H; UL16-binding protein 2; ULBP2 and N2DL2; is cell membrane protein which belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus; but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor; together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells; resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2; STAT5; ERK and PI3K kinase/Akt signal transduction pathway.
Product Name:
Human ULBP2/N2DL-2 Recombinant Protein (RPES0255)
Product Code:
RPES0255
Size:
100 µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
NKG2D Ligand 2, N2DL-2, NKG2DL2, ALCAN-Alpha, Retinoic Acid Early Transcript 1H, UL16-Binding Protein 2, ULBP2, N2DL2, RAET1H
Accession:
Q9BZM5
Sequence:
Met 1-Ser 217
Fusion tag:
C-Fc
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human ULBP2 (Q9BZM5) (Met 1-Ser 217);without the pro peptide; w was fused with the Fc region of human IgG1 at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
48.7 kDa
AP Mol Mass:
58 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
