The Recombinant Insulin Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110042) against INS. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB, IHC and ICC/IF applications. It has been validated by WB analysis of Mouse pancreas, Rat pancreas and IHC analysis of Human pancreas, Mouse pancreas, Rat pancreas. The target is localized to the secreted.
