null

Mouse IFNGR1 Recombinant Protein (RPES1391)

SKU:
RPES1391
Product Type:
Recombinant Protein
Species:
Mouse
€110
Frequently bought together:

Description

system_update_altDatasheet

Mouse IFNGR1 Recombinant Protein

The tetrameric receptor complex for IFN? consists of two subunits, IFNGR1 (IFN? R?) and IFNGR2 (IFN? Rβ), through which the dimeric IFN-? exerts its biological functions, including antiviral, antiproliferation and immune-modulatory activity in mammals. Both IFNGR1 and IFNGR2 are single transmembrane proteins belonging to the class II cytokine family. FNGR1, widely expressed in most host cells, is essential for IFN? binding, receptor trafficking, and signal transduction. IFNGR1 possesses an intracellular Janus tyrosine kinase (JAK) 1 binding site, a signal transducer and activator of transcription 1 (STAT1) binding site. The resulting STAT1 homodimers translocate from the cytoplasm to the nucleus and bind to the interferon-gamma activated sequence (GAS) promoter to induce expression of downstream interferon stimulated genes (ISGs).