Genetic studies in mouse and human suggest that kynureninase activity may influence blood pressure and renal function. The gene coding kynureninase (KYNU) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension was previously detected in the Chinese Han population.The results show that the rare KYNU variant Arg188Gln affects kynureninase activity and are consistent with the hypothesis that this mutation can predispose to essential hypertension.
Product Name:
Mouse KYNU/Kynureninase Recombinant Protein (RPES2982)
Product Code:
RPES2982
Size:
100 µg
Species:
Mouse
Expressed Host:
Baculovirus-Insect Cells
Synonyms:
4432411A05Rik
Accession:
Q9CXF0
Sequence:
Met 1-Ser 464
Fusion tag:
C-His
Activity:
Measured by its ability to oxidize 3-hydroxykynurenine.The specific activity is > 100 pmoles/min/µg.
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the mouse KYNU (Q9CXF0) (Met 1-Ser 464) was expressed?with a C-terminal polyhistidine tag.
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
