MARCO (macrophage receptor with collagenous structure) is an 80 kDa type II transmembrane glycoprotein that belongs to the class Ascavenger receptor family. Mouse MARCO consists of a 48 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 449 aa extracellulardomain (ECD) that includes a stalk region, a collagenlikeregion, and one SRCR domain. MARCO is constitutively expressed on the surface of splenic and lymph node macrophages. MARCO binds LPS, lipoteichoic acid, and otherdeterminants on Gram positive and Gram negative bacteria. It also binds modified LDL, CpG oligonucleotides, UGRP1, silica, and TiO2.
Product Name:
Mouse MARCO Recombinant Protein (RPES1122)
Product Code:
RPES1122
Size:
10µg
Species:
Mouse
Expressed Host:
Human Cells
Synonyms:
Macrophage receptor MARCO, Marco, Macrophage receptor with collagenous structure,Ly112,Scara2
Accession:
Q60754
Sequence:
Gln70-Ser518
Fusion tag:
N-His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Mouse MARCO is produced by our Mammalian expression system and the target gene encoding Gln70-Ser518 is expressed with a 8His tag at the N-terminus.
Purity:
> 90% as determined by reducing SDS-PAGE.
Mol Mass:
46.2 kDa
AP Mol Mass:
55-65 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
