The Recombinant Nestin Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C311233) against Nestin. Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB, IHC, ICC/IF and FC applications. It has been validated by IF analysis of U-87MG. The target is localized to the cytoskeleton, cytoplasm.