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Recombinant Nibrin Monoclonal Antibody (AGEL6069)

Datasheet MSDS
SKU AGEL6069
Product Type Antibody
Reactivity Human, Mouse, Rat
Applications WB, IHC, IF, IP, ELISA
Host Species Rabbit
Clonality Monoclonal
Clone C110761
Conjugate Unconjugated
€409 - €559

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Description

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Recombinant Nibrin Monoclonal Antibody

The Recombinant Nibrin Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110761) against Nibrin. Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.

This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by WB analysis of PC-12 and IHC analysis of Human kidney. The target is localized to the nucleus, nucleus, PML body, chromosome, telomere, chromosome, Localizes to discrete nuclear foci after treatment with genotoxic agents (PubMed:26438602, PubMed:10783165, PubMed:26215093). Acetylation of 'Lys-5' of histone H2AX (H2AXK5ac) promotes NBN/NBS1 assembly at the sites of DNA damage (PubMed:26438602).

Product Name:Recombinant Nibrin Monoclonal Antibody
SKU:AGEL6069
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:AT V1, AT V2, AT-V1, AT-V2, ATV, Cell cycle regulatory protein p, Cell cycle regulatory protein p95, FLJ10155, MGC, MGC87362, NBN, NBS, NBS 1, NBS1, nibrin, Nijmegen breakage syndrome, Nijmegen breakage syndrome 1 (nibrin), Nijmegen breakage syndrome protein, Nijmegen breakage syndrome protein 1, P95, p95 protein of the MRE11/RAD50 complex
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant Human Nibrin protein
Applications:WBIHCIFIPELISA
Clonality:Recombinant Monoclonal
Clone No:C110761
Host:Rabbit
Isotype:Rabbit IgG
Target:Nibrin
Conjugation:Unconjugated
Observed MW:95 kDa
Calculated MW:85 kDa
Recommended Dilution:IHC 1:200-1000; WB 1:2000-10000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200
UniProt:O60934
Purification:Protein A
Concentration:0.2 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
Product ImageImmunohistochemistry of paraffin-embedded human kidney using Recombinant Nibrin Monoclonal Antibody at dilution of 1:200.
Product ImageWestern Blot with Recombinant Nibrin Monoclonal Antibody at dilution of 1:1000 dilution. Lane A: PC-12 lysate. Observed-MW:95 kDa Calculated-MW:85 kDa
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