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Key Features

Recombinant Nucleophosmin Monoclonal Antibody (AGEL6053)

Datasheet MSDS
SKU AGEL6053
Product Type Antibody
Reactivity Human, Mouse, Rat
Applications WB, IHC, IF, IP, ELISA
Host Species Rabbit
Clonality Monoclonal
Clone C110745
Conjugate Unconjugated
$540 - $738

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Description

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Recombinant Nucleophosmin Monoclonal Antibody

The Recombinant Nucleophosmin Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110745) against Nucleophosmin. This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.

This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by WB analysis of T47D and IHC analysis of Human liver. The target is localized to the nucleus, nucleolus, nucleus, nucleoplasm, cytoplasm, cytoskeleton, microtubule organizing center, centrosome, generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co- localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis.

Product Name:Recombinant Nucleophosmin Monoclonal Antibody
SKU:AGEL6053
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:B23, NPM, NPM1, Nucleophosmin
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant Human Nucleophosmin protein
Applications:WBIHCIFIPELISA
Clonality:Recombinant Monoclonal
Clone No:C110745
Host:Rabbit
Isotype:Rabbit IgG
Target:Nucleophosmin
Conjugation:Unconjugated
Observed MW:38 kDa
Calculated MW:33 kDa
Recommended Dilution:IHC 1:200-1000; WB 1:2000-10000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200
UniProt:P06748
Purification:Protein A
Concentration:0.2 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
Product ImageImmunohistochemistry of paraffin-embedded human liver using Recombinant Nucleophosmin Monoclonal Antibody at dilution of 1:200.
Product ImageWestern Blot with Recombinant Nucleophosmin Monoclonal Antibody at dilution of 1:1000 dilution. Lane A: T47D lysate. Observed-MW:38 kDa Calculated-MW:33 kDa
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