The Recombinant OPA1 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110888) against OPA1. This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB, IHC, IF and ELISA applications. It has been validated by IHC analysis of Rat brain. The target is localized to the mitochondrion inner membrane, single-pass membrane protein, mitochondrion intermembrane space, mitochondrion membrane, detected at contact sites between endoplasmic reticulum and mitochondrion membranes.