The Recombinant PAX8 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C141243) against PAX8. PAX8 is one of nine transcription factors within the PAX gene family. It has been observed to be expressed during embryonic development however expression attenuates after development in all but a few tissues. Research has indicated that over-expression of PAX proteins in general are not an initiating event in tumorgenesis however they may facilitate malignant development. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for IHC and IF applications. It has been validated by IHC analysis of Human thyroid, Mouse thyroid, Rat thyroid and IF analysis of SK-OV-3. The target is localized to the nucleus.