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Recombinant PD1 Monoclonal Antibody (AGEL6349)

Datasheet MSDS
SKU AGEL6349
Product Type Antibody
Reactivity Human
Applications IHC, IF
Host Species Rabbit
Clonality Monoclonal
Clone C341043
Conjugate Unconjugated
$606 - $843

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Description

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Recombinant PD1 Monoclonal Antibody

The Recombinant PD1 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C341043) against PD1. The programmed cell death 1 protein (PD1) is an inhibitory receptor expressed on antigen activated T-cells that plays a critical role in the induction and maintenance of immune tolerance to self-antigens. Upon binding to its ligands CD274/PDCD1L1 (PD-L1) and CD273/PDCD1LG2 (PD-L2), PD1 is phosphorylated within its immunoreceptor tyrosine-based switch motif (ITSM), which facilitates the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2. PTPN11/SHP-2 then dephosphorylates key T-cell receptor (TCR) proximal signaling molecules, including ZAP70, PRKCQ/PKC theta and CD247/CD3 zeta, leading to the direct inhibition of T-cell activation. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.

This antibody is suitable for IHC and IF applications. It has been validated by IHC analysis of Human spleen, Human tonsil and IF analysis of Molt4. The target is localized to the membrane.

Product Name:Recombinant PD1 Monoclonal Antibody
SKU:AGEL6349
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:CD279, CD279 antigen, hPD, hPD 1, hPD l, hPD-1, hPD-l, hSLE, hSLE1, PD 1, PD-1, PD1, PDCD 1, PDCD1, programmed cell death, programmed cell death 1, Programmed cell death 1 protein, Programmed cell death protein, Programmed cell death protein 1, Programmed Death, Programmed Death-1, Protein PD 1, Protein PD-1, SLEB, SLEB2, Systemic lupus erythematosus susceptibility, Systemic lupus erythematosus susceptibility 2
Reactivity:Human
Immunogen:Synthetic peptide derived from the human PD1 protein
Applications:IHCIF
Clonality:Recombinant Monoclonal
Clone No:C341043
Host:Rabbit
Isotype:Rabbit IgG
Target:PD1
Conjugation:Unconjugated
Recommended Dilution:IHC 1:200-1000; IF 1:50
UniProt:Q15116
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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