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Recombinant Phospho-Rpb1 (Ser5) Monoclonal Antibody (RMEA0789)

Datasheet MSDS
SKU RMEA0789
Product Type Antibody
Reactivity Human, Mouse, Rat
Applications WB, IHC, IF, IP, ELISA
Host Species Rabbit
Clonality Monoclonal
Clone C110787
Conjugate Unconjugated
€409 - €559

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Description

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Recombinant Phospho-Rpb1 (Ser5) Monoclonal Antibody

The Recombinant Phospho-Rpb1 (Ser5) Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110787) against Rpb1 (Ser5). This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.

This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by WB analysis of NIH-3T3 and IHC analysis of Human colon. The target is localized to the nucleus, cytoplasm, chromosome, hypophosphorylated form is mainly found in the cytoplasm, while the hyperphosphorylated and active form is nuclear (PubMed:26566685). Co-localizes with kinase SRPK2 and helicase DDX23 at chromatin loci where unscheduled R-loops form (PubMed:28076779).

Product Name:Recombinant Phospho-Rpb1 (Ser5) Monoclonal Antibody
SKU:RMEA0789
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:hRPB, hRPB220, hsRPB, hsRPB1, Pol II, POLR, POLR2, POLR2A, POLRA, RPB, RPB1, RPBh, RPBh1, RpIILS, RPO, RPO2, RPOL, RPOL2
Reactivity:Human, Mouse, Rat
Immunogen:A synthetic peptide corresponding to residues around (Ser5) of Human Phospho-Rpb1
Applications:WBIHCIFIPELISA
Clonality:Recombinant Monoclonal
Clone No:C110787
Host:Rabbit
Isotype:Rabbit IgG
Target:Rpb1 (Ser5)
Conjugation:Unconjugated
Observed MW:217 kDa
Calculated MW:217 kDa
Recommended Dilution:IHC 1:200-1000; WB 1:500-2000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200
UniProt:P24928
Purification:Protein A
Concentration:0.2 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
Product ImageImmunohistochemistry of paraffin-embedded human colon using Recombinant Phospho-Rpb1 (Ser5) Monoclonal Antibody at dilution of 1:200.
Product ImageWestern Blot with Recombinant Phospho-Rpb1 (Ser5) Monoclonal Antibody at dilution of 1:1000 dilution. Lane A: NIH-3T3. Observed-MW:217 kDa Calculated-MW:217 kDa
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