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Recombinant PKR Monoclonal Antibody (AGEL5592)

Datasheet MSDS
SKU AGEL5592
Product Type Antibody
Reactivity Human, Mouse, Rat
Applications WB, IHC, IF, IP, ELISA
Host Species Rabbit
Clonality Monoclonal
Clone C110273
Conjugate Unconjugated
$540 - $738

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Description

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Recombinant PKR Monoclonal Antibody

The Recombinant PKR Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110273) against PKR. The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.

This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by WB analysis of HeLa, THP-1, SH-SY5Y, MCF-7, A549, Jurkat. The target is localized to the cytoplasm, nucleus, cytoplasm, perinuclear region, nuclear localization is elevated in acute leukemia, myelodysplastic syndrome (MDS), melanoma, breast, colon, prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced Creutzfeldt-Jakob disease patients.

Product Name:Recombinant PKR Monoclonal Antibody
SKU:AGEL5592
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:Double stranded RNA activated protein kinase, double-stranded RNA-activated protein kinase, E2AK2, eIF-2A protein kinase 2, EIF2AK1, Eif2ak2, Eukaryotic translation initiation factor 2 alpha kinase 2, Eukaryotic translation initiation factor 2-alpha kinase 2, HGNC:9437, Interferon induced double stranded RNA activated protein kinase, Interferon inducible elF2 alpha kinase, Interferon inducible RNA dependent protein kinase, Interferon-induced, Interferon-inducible RNA-dependent protein kinase, MGC126524, P1/eIF-2A protein kinase, P1/eIF2A protein kinase, p68 kinase, PKR, PPP1R, PPP1R83, PRKR, Protein kinase interferon inducible double stranded RNA dependent, Protein kinase RNA activated, Protein kinase RNA-activated, Protein phosphatase 1 regulatory subunit 83, Serine/threonine protein kinase TIK, Tyrosine protein kinase EIF2AK2
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant Human PKR protein
Applications:WBIHCIFIPELISA
Clonality:Recombinant Monoclonal
Clone No:C110273
Host:Rabbit
Isotype:Rabbit IgG
Target:PKR
Conjugation:Unconjugated
Observed MW:62 kDa
Calculated MW:62 kDa
Recommended Dilution:IHC 1:100-500; WB 1:2000-10000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200
UniProt:P19525
Purification:Protein A
Concentration:0.2 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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