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Key Features

Recombinant SMC1A Monoclonal Antibody (AGEL6912)

SKU AGEL6912
Product Type Antibody
Reactivity Human, Mouse
Applications WB
Host Species Rabbit
Clonality Monoclonal
Clone C231607
Conjugate Unconjugated
$606 - $843

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Description

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Recombinant SMC1A Monoclonal Antibody

The Recombinant SMC1A Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C231607) against SMC1A. he cohesin complex consists of a heterodimer between SMC1 (SMC1A or B) and SMC3, bound by additional RAD21 and STAG proteins (STAG1, 2, or 3). These proteins form a ring-like structure that mediates the cohesion of two sister chromatids after DNA replication in S phase. RAD21 and STAG2 are phosphorylated by Polo-like kinase (PLK) during prophase, which leads to the dissociation of cohesin complexes from the chromosome arms; however, cohesin remains bound to centromeres until anaphase. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human and Mouse samples.

This antibody is suitable for WB applications. It has been validated by WB analysis of SW480,?HepG2, 4T1, NIH/3T3. The target is localized to the nucleus.

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