The Recombinant Sortilin Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110789) against Sortilin. This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB, IHC, IF and ELISA applications. It has been validated by IHC analysis of Human brain. The target is localized to the Golgi apparatus, Golgi stack membrane, Single-pass type I membrane protein, endosome membrane, Single-pass type I membrane protein, endoplasmic reticulum membrane, Single-pass type I membrane protein, nucleus membrane, Single-pass type I membrane protein, Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane, Single-pass type I membrane protein, localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin.