The Recombinant TDP43 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110587) against TDP43. HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by WB analysis of SH-SY5Y. The target is localized to the nucleus.
Product Name:
Recombinant TDP43 Monoclonal Antibody
SKU:
AGEL5901
Size:
50 µL, 100 µL
Antibody Type:
Recombinant Monoclonal Antibody
Synonyms:
along with a truncated 20-28 kDa form, ALS, ALS10, and 99% aa identity with rat TDP-43., human and mouse TDP-43 share 100% aa sequence identity, in ubiquitin-containing inclusion bodies. TDP-43 can also influence CFTR exon 9 skipping in cystic fibrosis. Within aa 1-103, TADBP, TARDBP, TDP, TDP-43, TDP43
Reactivity:
Human, Mouse, Rat
Immunogen:
Recombinant Human TDP43 protein
Applications:
WBIHCIFIPELISA
Clonality:
Recombinant Monoclonal
Clone No:
C110587
Host:
Rabbit
Isotype:
Rabbit IgG
Target:
TDP43
Conjugation:
Unconjugated
Observed MW:
45 kDa
Calculated MW:
45 kDa
Recommended Dilution:
IHC 1:200-1000; WB 1:1000-5000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200
UniProt:
Q13148
Purification:
Protein A
Concentration:
0.2 mg/mL
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:
Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
Western Blot with Recombinant TDP43 Monoclonal Antibody at dilution of 1:1000 dilution. Lane A: SH-SY5Y cells. Observed-MW:45 kDa Calculated-MW:45 kDa
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