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Recombinant TFF1/pS2 Monoclonal Antibody (AGEL6818)

Datasheet MSDS
SKU AGEL6818
Product Type Antibody
Reactivity Human
Applications WB, IHC
Host Species Rabbit
Clonality Monoclonal
Clone C321513
Conjugate Unconjugated
$606 - $843

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Description

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Recombinant TFF1/pS2 Monoclonal Antibody

The Recombinant TFF1/pS2 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C321513) against TFF1/pS2. TFF1/pS2 is a gastric peptide that is highly expressed by mucosal goblet cells of the stomach, where it is thought to play a role in maintaining the integrity of the epithelial layer of the mucosa through the regulation of cell-cell adhesion and cell migration. Research studies have shown that TFF1 functions as a tumor suppressor in the stomach as its expression is frequently lost in gastric carcinomas, largely due to promoter hypermethylation. Research studies have also demonstrated that TFF1 is a transcriptional target of estrogen receptor-α and that TFF1 expression in breast carcinoma may be used as a predictive biomarker for response to anti-estrogen therapy. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.

This antibody is suitable for WB and IHC applications. It has been validated by WB analysis of MDA-MB-231(Negative control), MCF-7 and IHC analysis of Human colon cancer, Human stomach. The target is localized to the secreted.

Product Name:Recombinant TFF1/pS2 Monoclonal Antibody
SKU:AGEL6818
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:BCEI, Breast cancer estrogen-inducible protein, D21S, D21S21, HP1.A, HPS, HPS2, pNR, pNR-2, Polypeptide P1.A, Protein Ps, Protein Ps2, pS2, TFF, TFF1, Trefoil factor, Trefoil factor 1
Reactivity:Human
Immunogen:Recombinant human TFF1/pS2 fragment
Applications:WBIHC
Clonality:Recombinant Monoclonal
Clone No:C321513
Host:Rabbit
Isotype:Rabbit IgG
Target:TFF1/pS2
Conjugation:Unconjugated
Observed MW:13 kDa
Calculated MW:10 kDa
Recommended Dilution:WB 1:500-2000; IHC 1:50-100
UniProt:P04155
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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