The Recombinant TRIM21 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C333277) against TRIM21. This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus.RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Produced by recombinant technology in Rabbit hosts and purified by affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB applications. It has been validated by WB analysis of K562, Hela. The target is localized to the Cytoplasm. Nucleus. Cytoplasm>P-body. Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body.
Product Name:
Recombinant TRIM21 Monoclonal Antibody
SKU:
AGEL8582
Size:
50 µL, 100 µL
Antibody Type:
Recombinant Monoclonal Antibody
Synonyms:
52 kDa ribonucleoprotein autoantigen Ro/SS-A, 52 kDa Ro protein, 52-KD, 52kD Ro/SSA autoantigen, Autoantigen Ro/SSA, E3 ubiquitin-protein ligase TRIM21, RING finger protein 81, RNF81, Ro 52, Ro(SS-A), RO52, Sicca syndrome antigen A, Sjoegren syndrome type A anti, Sjoegren syndrome type A antigen, Sjogren syndrome antigen A1, Sjogren syndrome type A antigen, SS-A, SSA, SSA1: Sjogren syndrome antigen A1 (52kDa ribonucleoprotein autoantigen SS-A/Ro), TRIM21, Tripartite motif protein TRIM21, Tripartite motif-containing 21, Tripartite motif-containing protein 21
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