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Recombinant VEGF Receptor 2 Monoclonal Antibody (RMEA0943)

Datasheet MSDS
SKU RMEA0943
Product Type Antibody
Reactivity Human, Mouse, Rat
Applications WB, IHC, IF, IP, ELISA
Host Species Rabbit
Clonality Monoclonal
Clone C110942
Conjugate Unconjugated
$540 - $738

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Description

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Recombinant VEGF Receptor 2 Monoclonal Antibody

The Recombinant VEGF Receptor 2 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110942) against VEGF Receptor 2. Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.

This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by WB analysis of Rat heart. The target is localized to the cell junction, endoplasmic reticulum, cell membrane, Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610), Cell membrane; Single-pass type I membrane protein. Cytoplasm, nucleus, Cytoplasmic vesicle. Early endosome. Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus, secreted, secreted.

Product Name:Recombinant VEGF Receptor 2 Monoclonal Antibody
SKU:RMEA0943
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:6130401C, 6130401C07, CD309, Fetal liver kinase, Fetal liver kinase 1, FLK, FLK-1, FLK1, KDR, Kinase insert domain receptor, Krd, Krd-1, Ly73, Protein-tyrosine kinase receptor flk, Protein-tyrosine kinase receptor flk-1, sVEGFR, sVEGFR-2, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, VEGF R, VEGF R2, VEGF Receptor, VEGF Receptor 2, VEGFR, VEGFR-2, VEGFR2
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant Human VEGF Receptor 2 protein
Applications:WBIHCIFIPELISA
Clonality:Recombinant Monoclonal
Clone No:C110942
Host:Rabbit
Isotype:Rabbit IgG
Target:VEGF Receptor 2
Conjugation:Unconjugated
Observed MW:230 kDa
Calculated MW:151 kDa
Recommended Dilution:IHC 1:1000-4000; WB 1:2000-10000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200
UniProt:P35968
Purification:Protein A
Concentration:0.2 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
Product ImageWestern Blot with Recombinant VEGF Receptor 2 Monoclonal Antibody at dilution of 1:1000 dilution. Lane A: Rat heart cell lysate. Observed-MW:230 kDa Calculated-MW:151 kDa
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