Description
Retinoid X Receptor gamma Transcription Factor Activity Assay
The Retinoid X Receptor Gamma Transcription Factor Activity Assay kit from AssayGenie is a powerful tool for studying the activity of the retinoid X receptor gamma transcription factor. This kit is designed for accurate detection and quantification of RXR gamma activity in cell lysates, serum, plasma, and tissue homogenates.The assay features high sensitivity and specificity, ensuring reliable and reproducible results for your research needs. The Retinoid X Receptor Gamma Transcription Factor Activity Assay kit is ideal for investigating the role of RXR gamma in gene regulation, cell differentiation, and various diseases such as cancer, diabetes, and metabolic disorders.
By using this assay kit, researchers can gain valuable insights into the biological functions of RXR gamma and potentially identify new therapeutic targets for treating diseases associated with dysregulated retinoid signaling. Upgrade your research with the Retinoid X Receptor Gamma Transcription Factor Activity Assay kit from AssayGenie.
| Product Name: | Retinoid X Receptor gamma Transcription Factor Activity Assay |
| Product Code: | TFAB00176 |
| Target: | Retinoid X Receptor gamma |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie Retinoid X Receptor gamma transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | RXRG: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Belongs to the nuclear hormone receptor family. NR2 subfamily. |
| UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor Chromosomal Location of Human Ortholog: 1q22-q23 Cellular Component: nucleoplasm Molecular Function:protein binding; zinc ion binding; retinoid-X receptor activity; steroid hormone receptor activity Biological Process: retinoic acid receptor signaling pathway; neuron differentiation; transcription initiation from RNA polymerase II promoter; skeletal muscle development; response to retinoic acid; regulation of myelination; heart development; steroid hormone mediated signaling; gene expression; transmembrane transport; protein homotetramerization; peripheral nervous system development |
| NCBI Summary: | This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P48443 |
| NCBI GenInfo Identifier: | 1350913 |
| NCBI Gene ID: | 6258 |
| NCBI Accession: | P48443.1 |
| UniProt Secondary Accession: | P48443,Q6IBU7, A6NIP1, |
| UniProt Related Accession: | P48443 |
| Molecular Weight: | 50,871 Da |
| NCBI Full Name: | Retinoic acid receptor RXR-gamma |
| NCBI Synonym Full Names: | retinoid X receptor, gamma |
| NCBI Official Symbol: | RXRG |
| NCBI Official Synonym Symbols: | RXRC; NR2B3 |
| NCBI Protein Information: | retinoic acid receptor RXR-gamma; nuclear receptor subfamily 2 group B member 3 |
| UniProt Protein Name: | Retinoic acid receptor RXR-gamma |
| UniProt Synonym Protein Names: | Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma |
| UniProt Gene Name: | RXRG |
| UniProt Entry Name: | RXRG_HUMAN |
