Rezorstobart Antibody is a research-grade biosimilar monoclonal antibody. It is a human IgG1-kappa antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Killer cell lectin-like receptor subfamily B member 1 (CD161/KLRB1) is a ~25 kDa protein. Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Product Name:
Rezorstobart Antibody
SKU:
GXBS02208
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
CLEC5B
Isotype:
IgG1-kappa
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FACS, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
2762201-86-3
Biological Activity:
CD161 has K i s of 8.2 nM and 1.4 nM for BRD4 BD1 and BRD4 BD2, respectively [1]. CD161 (30-3000 nM; 1 hours) is very effective in inducing rapid down-regulation of c-Myc at as early as the 1 h time point and in a dose-dependent manner [1]. Western Blot Analysis [1] Cell Line: MV4;11 leukemia cells. Concentration: 30, 100, 300, 1000, 3000 nM Incubation Time: 1 hours Result: Induced rapid down-regulation of c-Myc at as early as the 1 hours time point and in a dose-dependent manner. CD161 (po; 20, 40 mg/kg/day; 45 days) achieves essentially complete tumor growth inhibition [1]. CD161 (5 mg/kg (iv), 25 mg/kg (po); 0-24 hours) has the t 1/2 of 2.4 hours (iv) and 2.9 hours (po) for rat; the C max of 7333 ng/mL (po) for rat. The t 1/2 of mice is 0.5 hours (iv) and 1.60 hours (po); the C max of mice is 983.1 ng/mL (po) [1].
Purity:
>95% purity as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
