Anti-RHOA/RHOB/RHOC Antibody (CAB4855)

Product Name:	RHOA/RHOB/RHOC Rabbit mAb
Product Code:	CAB4855
Size:	20uL, 50uL, 100uL
Synonyms:	ARH9, ARHC, H9, RHOH9
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human RHOA/RHOB/RHOC

Applications:	WB, IHC, IF
Recommended Dilutions:	WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, MCF7, NIH/3T3, SH-SY5Y, HUVEC, Mouse brain, Mouse kidney, Rat brain

Immunogen:	A synthesized peptide derived from human RHOA/RHOB/RHOC
Purification Method:	Affinity purification
Storage:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	389/387/388
Uniprot:	P08134/P61586/P62745
Calculated MW:	22kDa
Observed MW:	22KDa

UniProt Protein Function:	RHOC: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.
UniProt Protein Details:	Protein type:G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, Rho; G protein Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: cleavage furrow; cytosol; plasma membrane Molecular Function:protein binding; signal transducer activity Biological Process: apical junction assembly; cytokinesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of lipase activity; regulation of small GTPase mediated signal transduction
NCBI Summary:	This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:	P08134
NCBI GenInfo Identifier:	132543
NCBI Gene ID:	389
NCBI Accession:	P08134.1
UniProt Secondary Accession:	P08134,Q6ICN3, B3KSW1,
UniProt Related Accession:	P08134
Molecular Weight:	22,006 Da
NCBI Full Name:	Rho-related GTP-binding protein RhoC
NCBI Synonym Full Names:	ras homolog family member C
NCBI Official Symbol:	RHOC
NCBI Official Synonym Symbols:	H9; ARH9; ARHC; RHOH9
NCBI Protein Information:	rho-related GTP-binding protein RhoC
UniProt Protein Name:	Rho-related GTP-binding protein RhoC
UniProt Synonym Protein Names:	Rho cDNA clone 9; h9
Protein Family:	Rho-related GTP-binding protein
UniProt Gene Name:	RHOC
UniProt Entry Name:	RHOC_HUMAN