Sevirumab Antibody is a research-grade biosimilar monoclonal antibody targeting Envelope glycoprotein H. It is a human IgG1, kappa antibody. Reactivity: Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5). Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Envelope glycoprotein H (gHUL75) is a ~84 kDa protein. The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. In human cytomegalovirus, forms two distinct complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope. The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA, and in glioblastoma cells by interacting with host EPHA2.
Product Name:
Sevirumab Antibody
SKU:
GXBS00494
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
Envelope glycoprotein H
Isotype:
IgG1, kappa
Host Species:
Human
Reactivity:
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Applications:
ELISA, FACS, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
EV27, MSL109, SDZMSL109, 138660-96-5
Purity:
>95% purity as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
