Description
SIV gp120 Recombinant Protein (C-His)
SIV gp120 Recombinant Protein (C-His) is a recombinant protein expressed in mammalian cells, spanning Ile20-Ser523, with a C-terminal His tag. Predicted molecular weight: 60.67 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Envelope glycoprotein gp160 is a ~101 kDa protein. The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. For research use only.
This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide.
| Product Name: | SIV gp120 Recombinant Protein (C-His) |
| SKU: | GXRP10239 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | SIV |
| Synonyms: | Envelope glycoprotein gp160, Env polyprotein, Surface protein gp120, SU, Glycoprotein 120, gp120, Transmembrane protein gp41, TM, Glycoprotein 32, gp32, env |
| Tag: | C-His |
| Expression Host: | Mammalian cells |
| Protein Length: | Ile20-Ser523 |
| Calculated MW: | 60.67 kDa |
| UniProt: | P08810 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
