| UniProt Protein Function: | SLC13A5: High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol. Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC familyChromosomal Location of Human Ortholog: 17p13.1Cellular Component: basolateral plasma membrane; integral to membrane; plasma membraneMolecular Function: citrate transmembrane transporter activity; succinate transmembrane transporter activity; sodium:dicarboxylate symporter activityBiological Process: citrate transport; sodium ion transport; transmembrane transportDisease: Epileptic Encephalopathy, Early Infantile, 25 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause early infantile epileptic encephalopathy 25. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] |
| UniProt Code: | Q86YT5 |
| NCBI GenInfo Identifier: | 219802232 |
| NCBI Gene ID: | 284111 |
| NCBI Accession: | NP_001137310.1 |
| UniProt Secondary Accession: | Q86YT5,Q6ZMG1, B3KXR0, B7Z4P2, B7ZLB4, F8W7N2 |
| UniProt Related Accession: | Q86YT5 |
| Molecular Weight: | 58,092 Da |
| NCBI Full Name: | solute carrier family 13 member 5 isoform b |
| NCBI Synonym Full Names: | solute carrier family 13 (sodium-dependent citrate transporter), member 5 |
| NCBI Official Symbol: | SLC13A5Â Â |
| NCBI Official Synonym Symbols: | NACT; mIndy; EIEE25Â Â |
| NCBI Protein Information: | solute carrier family 13 member 5; Na(+)/citrate cotransporter; Na+-coupled citrate transporter protein; sodium-dependent dicarboxylate transporter |
| UniProt Protein Name: | Solute carrier family 13 member 5 |
| UniProt Synonym Protein Names: | Na(+)/citrate cotransporter; NaCT; Sodium-coupled citrate transporter; Sodium-dependent citrate transporter |
| Protein Family: | |
| UniProt Gene Name: | SLC13A5Â Â |
| UniProt Entry Name: | S13A5_HUMAN |
