| UniProt Protein Function: | SLC1A4: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral Chromosomal Location of Human Ortholog: 2p15-p13 Cellular Component: centrosome; cell surface; cell soma; membrane; integral to plasma membrane; dendrite; melanosome; integral to membrane; plasma membrane; intermediate filament; microtubule organizing center Molecular Function:L-serine transmembrane transporter activity; chloride channel activity; L-threonine transmembrane transporter activity; L-proline transmembrane transporter activity; L-alanine transmembrane transporter activity; L-glutamine transmembrane transporter activity; L-cystine transmembrane transporter activity; sodium:dicarboxylate symporter activity Biological Process: synaptic transmission, glutamatergic; threonine transport; L-cystine transport; chloride transport; L-serine transport; L-alanine transport; dicarboxylic acid transport; amino acid transport; ion transport; cognition; proline transport; glutamine transport; transmembrane transport |
| NCBI Summary: | The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability. [provided by RefSeq, Jan 2017] |
| UniProt Code: | P43007 |
| NCBI GenInfo Identifier: | 1173365 |
| NCBI Gene ID: | 6509 |
| NCBI Accession: | P43007.1 |
| UniProt Related Accession: | P43007 |
| Molecular Weight: | ~56kDa |
| NCBI Full Name: | Neutral amino acid transporter A |
| NCBI Synonym Full Names: | solute carrier family 1 member 4 |
| NCBI Official Symbol: | SLC1A4Â Â |
| NCBI Official Synonym Symbols: | SATT; ASCT1; SPATCCMÂ Â |
| NCBI Protein Information: | neutral amino acid transporter A |
| UniProt Protein Name: | Neutral amino acid transporter A |
| UniProt Synonym Protein Names: | Alanine/serine/cysteine/threonine transporter 1; ASCT-1; SATT; Solute carrier family 1 member 4 |
| Protein Family: | Neutral amino acid transporter |
| UniProt Gene Name: | SLC1A4Â Â |
| UniProt Entry Name: | SATT_HUMAN |
