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Anti-SLC25A38 Antibody (CAB13218)

SKU:
CAB13218
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 1 Anti-SLC25A38 Antibody CAB13218
  • Signal Transduction Antibodies 1 Anti-SLC25A38 Antibody CAB13218
€139 - €419
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Description

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Antibody Name:Anti-SLC25A38 Antibody
Antibody SKU:CAB13218
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 140-220 of human SLC25A38 (NP_060345.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 140-220 of human SLC25A38 (NP_060345.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CMSP ITVI KTRY ESGK YGYE SIYA ALRS IYHS EGHR GLFS GLTA TLLR DAPF SGIY LMFY NQTK NIVP HDQV DATL IPIT N
Gene ID:54977
Uniprot:Q96DW6
Cellular Location:Mitochondrion inner membrane, Multi-pass membrane protein
Calculated MW:33kDa
Observed MW:33kDa
Synonyms:SLC25A38, SIDBA2
Background:This gene is a member of the mitochondrial carrier family. The encoded protein is required during erythropoiesis and is important for the biosynthesis of heme. Mutations in this gene are the cause of autosomal congenital sideroblastic anemia.
UniProt Protein Function:SLC25A3: Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). Defects in SLC25A3 are a cause of mitochondrial phosphate carrier deficiency (MPCD). MPCD is a fatal disorder of oxidative phosphorylation. Patients have lactic acidosis, hypertrophic cardiomyopathy and muscular hypotonia and die within the first year of life. Belongs to the mitochondrial carrier family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Mitochondrial; Transporter

Chromosomal Location of Human Ortholog: 12q23

Cellular Component: membrane; mitochondrion; integral to plasma membrane; mitochondrial inner membrane

Molecular Function:phosphate carrier activity; symporter activity; protein complex binding

Biological Process: generation of precursor metabolites and energy; transport

Disease: Mitochondrial Phosphate Carrier Deficiency

NCBI Summary:This gene is a member of the mitochondrial carrier family. The encoded protein is required during erythropoiesis and is important for the biosynthesis of heme. Mutations in this gene are the cause of autosomal congenital sideroblastic anemia (anemia, sideroblastic, 2, pyridoxine-refractory). A related pseudogene is found on chromosome 1. [provided by RefSeq, Aug 2017]
UniProt Code:Q96DW6
NCBI GenInfo Identifier:157388925
NCBI Gene ID:54977
NCBI Accession:NP_060345
UniProt Secondary Accession:Q96DW6,Q96DW6,
UniProt Related Accession:Q96DW6
Molecular Weight:33kDa
NCBI Full Name:mitochondrial glycine transporter isoform 1
NCBI Synonym Full Names:solute carrier family 25 member 38
NCBI Official Symbol:SLC25A38  
NCBI Official Synonym Symbols:SIDBA2  
NCBI Protein Information:mitochondrial glycine transporter
UniProt Protein Name:Phosphate carrier protein, mitochondrial
UniProt Synonym Protein Names:Phosphate transport protein; PTP; Solute carrier family 25 member 3
UniProt Gene Name:SLC25A3  
UniProt Entry Name:MPCP_HUMAN
Anti-SLC25A38 Antibody (CAB13218)Western blot analysis of extracts of 293T cells, using SLC25A38 antibody (CAB13218) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-SLC25A38 Antibody (CAB13218)Immunofluorescence analysis of NIH/3T3 cells using SLC25A38 antibody (CAB13218) at dilution of 1:100. Blue: DAPI for nuclear staining.

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