Anti-SOCS2 Antibody (CAB9190)
- SKU:
- CAB9190
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Developmental Biology
Description
Anti-SOCS2 Antibody (CAB9190)
The SOCS2 Rabbit Monoclonal Antibody (CAB9190) is a powerful tool for researchers studying the suppressor of cytokine signaling 2 (SOCS2) protein. This monoclonal antibody, generated in rabbits, is highly specific for SOCS2 and is validated for use in various applications, including Western blotting and immunohistochemistry.SOCS2 is a key regulator of cytokine signaling pathways, playing a crucial role in immune response, inflammation, and development. Dysregulation of SOCS2 has been implicated in various diseases, including cancer, autoimmune disorders, and metabolic conditions.
By targeting SOCS2, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic strategies.With its high specificity and sensitivity, the SOCS2 Rabbit Monoclonal Antibody (CAB9190) is an essential tool for researchers investigating the role of SOCS2 in health and disease. Its versatility in different applications makes it suitable for a wide range of experiments in the fields of immunology, oncology, and molecular biology. Start exploring the functions of SOCS2 with confidence using this reliable antibody.
| Antibody Name: | Anti-SOCS2 Antibody |
| Antibody SKU: | CAB9190 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human SOCS2 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, Mouse lung, Rat lung |
| Immunogen: | A synthesized peptide derived from human SOCS2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8835 |
| Uniprot: | O14508 |
| Cellular Location: | |
| Calculated MW: | 22kDa |
| Observed MW: | 21KDa |
| Synonyms: | CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2 |
| Background: | This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
| UniProt Protein Function: | SOCS2: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex. By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF. High expression in heart, placenta, lung, kidney and prostate. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 12q Cellular Component: cytoplasm; cytosol Molecular Function:insulin-like growth factor receptor binding; protein binding; growth hormone receptor binding; SH3/SH2 adaptor activity; protein kinase inhibitor activity; JAK pathway signal transduction adaptor activity Biological Process: positive regulation of signal transduction; cytokine and chemokine mediated signaling pathway; negative regulation of insulin receptor signaling pathway; protein ubiquitination; regulation of signal transduction; JAK-STAT cascade; response to estradiol stimulus; cellular response to hormone stimulus; negative regulation of protein kinase activity; regulation of cell growth; negative regulation of JAK-STAT cascade; aging; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
| UniProt Code: | O14508 |
| NCBI GenInfo Identifier: | 20178092 |
| NCBI Gene ID: | 8835 |
| NCBI Accession: | O14508.1 |
| UniProt Secondary Accession: | O14508,O14542, O95102, Q9UKS5, A8K3D1, |
| UniProt Related Accession: | O14508 |
| Molecular Weight: | 198 |
| NCBI Full Name: | Suppressor of cytokine signaling 2 |
| NCBI Synonym Full Names: | suppressor of cytokine signaling 2 |
| NCBI Official Symbol: | SOCS2Â Â |
| NCBI Official Synonym Symbols: | CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2Â Â |
| NCBI Protein Information: | suppressor of cytokine signaling 2; CIS-2; STAT induced STAT inhibitor-2; STAT-induced STAT inhibitor 2; STAT-induced STAT inhibitor-2; cytokine-inducible SH2 protein 2; suppressor of cytokine signaling-2 |
| UniProt Protein Name: | Suppressor of cytokine signaling 2 |
| UniProt Synonym Protein Names: | Cytokine-inducible SH2 protein 2; CIS-2; STAT-induced STAT inhibitor 2; SSI-2 |
| Protein Family: | Suppressor of cytokine signaling |
| UniProt Gene Name: | SOCS2Â Â |
| UniProt Entry Name: | SOCS2_HUMAN |
 | Western blot - SOCS2 Rabbit mAb (CAB9190) |
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