SOD1 (Cu/Zn) Antibody is a rabbit polyclonal antibody directed against SOD1 (Cu/Zn), offered by Assay Genie for research applications. Reported applications include WB, IHC, IP and ELISA. Reported reactivity: Human, Rat, Mouse, Bovine, Monkey, Invertebrate, Coral (Anthozoa), Dog, Hamster, Pig, Rabbit, Sheep, African clawed frog (Xenopus laevis), Mollusk, Mussel (Perna viridis) and Fish (O. melastigma). Purified by Protein A.
Superoxide dismutase 1 (SOD1) is a copper- and zinc-dependent antioxidant enzyme that plays a vital role in cellular defense against oxidative stress. Present in nearly all mammalian cells, SOD1 catalyzes the dismutation of superoxide radicals (O₂⁻) into hydrogen peroxide (H₂O₂) and molecular oxygen (O₂). These reactive oxygen species are subsequently detoxified by catalase and glutathione peroxidase, maintaining redox balance and protecting cells from oxidative damage. SOD1 functions as a 32 kDa homodimer, with each 16 kDa subunit stabilized by an intra-subunit disulfide bridge and a conserved β-barrel structure. It is primarily localized in the cytoplasm but also found in the nucleus and mitochondrial intermembrane space. Its structural integrity and metal-binding capacity are essential for enzymatic activity and cellular protection. In neuroscience and neurodegenerative disease research, SOD1 has gained prominence due to its association with amyotrophic lateral sclerosis (ALS). Mutations in the SOD1 gene can lead to protein misfolding, aggregation, and toxic gain-of-function effects, contributing to motor neuron degeneration. These pathological forms of SOD1 are key biomarkers and therapeutic targets in ALS and related disorders. Understanding the structure-function relationship of SOD1, particularly its metal coordination and dimerization, is critical for developing targeted interventions in oxidative stress-related neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
SOD1 (Cu/Zn) Antibody
Product SKU:
STPA00012
Size:
100 µg
Target:
SOD1 (Cu/Zn)
Host Species:
Rabbit
Antibody Type:
Polyclonal
Research Areas:
Cancer, Oxidative Stress, Cell Signaling, Protein Trafficking, Chaperone Proteins, Neuroscience, Neurodegeneration, ALS Disease
Buffer:
PBS pH7.0, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
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