Anti-STAU2 Antibody (CAB3413)

Antibody Name:	Anti-STAU2 Antibody
Antibody SKU:	CAB3413
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 300-400 of human STAU2 (NP_001157852.1).

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse heart, Mouse kidney, Rat heart, Rat brain

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 300-400 of human STAU2 (NP_001157852.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	PEYG QGMN PISR LAQI QQAK KEKE PDYV LLSE RGMP RRRE FVMQ VKVG NEVA TGTG PNKK IAKK NAAE AMLL QLGY KAST NLQD QLEK TGEN KGWS GPKP G
Gene ID:	27067
Uniprot:	Q9NUL3
Cellular Location:	Cytoplasm, Endoplasmic reticulum, Nucleus, nucleolus
Calculated MW:	11kDa/34kDa/43kDa/52kDa/55kDa/59kDa/62kDa
Observed MW:	52kDa

Synonyms:

STAU2, 39K2, 39K3

Background:

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	STAU2: RNA-binding protein required for the microtubule- dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Nuclear export; RNA-binding; Nucleolus Chromosomal Location of Human Ortholog: 8q21.11 Cellular Component: microtubule; membrane; endoplasmic reticulum; nucleolus Molecular Function:protein binding; double-stranded RNA binding Biological Process: transport
UniProt Code:	Q9NUL3
NCBI GenInfo Identifier:	73919458
NCBI Gene ID:
NCBI Accession:	Q9NUL3.1
Molecular Weight:	~ 52kDa
NCBI Full Name:	Double-stranded RNA-binding protein Staufen homolog 2
UniProt Protein Name:	Double-stranded RNA-binding protein Staufen homolog 2
Protein Family:	Double-stranded RNA-binding protein
UniProt Gene Name:	STAU2
UniProt Entry Name:	STAU2_HUMAN

	Western blot analysis of extracts of various cell lines, using STAU2 antibody (CAB3413) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
	Immunofluorescence analysis of U2OS cells using STAU2 antibody (CAB3413) at dilution of 1:100. Blue: DAPI for nuclear staining.

Antibodies

Anti-STAU2 Antibody (CAB14117)

STAU2 Antibody (PACO12518)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)