UniProt Protein Function: | Conversion of sulfated steroid precursors to estrogens during pregnancy. |
NCBI Summary: | This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016] |
UniProt Code: | P08842 |
NCBI GenInfo Identifier: | 135006 |
NCBI Gene ID: | 412 |
NCBI Accession: | P08842.2 |
UniProt Secondary Accession: | P08842,B2RA47, |
UniProt Related Accession: | P08842 |
Molecular Weight: | 65,492 Da |
NCBI Full Name: | Steryl-sulfatase |
NCBI Synonym Full Names: | steroid sulfatase (microsomal), isozyme S |
NCBI Official Symbol: | STSÂ Â |
NCBI Official Synonym Symbols: | ES; ASC; XLI; ARSC; SSDD; ARSC1Â Â |
NCBI Protein Information: | steryl-sulfatase |
UniProt Protein Name: | Steryl-sulfatase |
UniProt Synonym Protein Names: | Arylsulfatase C; ASC; Steroid sulfatase; Steryl-sulfate sulfohydrolase |
Protein Family: | STS14 protein |
UniProt Gene Name: | STSÂ Â |
UniProt Entry Name: | STS_HUMAN |