SUMO4 Rabbit Monoclonal Antibody (CAB9016)

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SKU:
CAB9016
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Description

Technical Manual

SUMO4 Rabbit Monoclonal Antibody

Product Name:SUMO4 Rabbit Monoclonal Antibody
Product SKU:CAB9016
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]

Immunogen:A synthesized peptide derived from human SUMO4
Sequence:

Email for sequence

Gene ID:387082
Swiss Prot:Q6EEV6
Synonyms:IDDM5; SMT3H4; SUMO-4; dJ281H8.4
Calculated MW:15kDa
Observed MW:17KDa
Reactivity:Human, Mouse, Rat
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry Immunofluorescence 
Positive Samples:293T, A-431, Raji, Mouse lung, Mouse brain, Rat lung
Cellular Location:

Product Images

SUMO4 Rabbit Monoclonal Antibody (CAB9016)

Western blot - SUMO4 Rabbit mAb (CAB9016)

Uniprot Information

UniProt Protein Function:SUMO4: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. Belongs to the ubiquitin family. SUMO subfamily.
UniProt Protein Details:

Protein type:Ubiquitin-like modifier

Chromosomal Location of Human Ortholog: 6q25

Cellular Component: nucleus

Biological Process: protein sumoylation

Disease: Diabetes Mellitus, Insulin-dependent, 5

NCBI Summary:This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]
UniProt Code:Q6EEV6
NCBI GenInfo Identifier:81175019
NCBI Gene ID:387082
NCBI Accession:Q6EEV6.2
UniProt Related Accession:Q6EEV6
Molecular Weight:~18kDa
NCBI Full Name:Small ubiquitin-related modifier 4
NCBI Synonym Full Names:small ubiquitin like modifier 4
NCBI Official Symbol:SUMO4 
NCBI Official Synonym Symbols:IDDM5; SMT3H4; SUMO-4; dJ281H8.4 
NCBI Protein Information:small ubiquitin-related modifier 4
UniProt Protein Name:Small ubiquitin-related modifier 4
UniProt Synonym Protein Names:Small ubiquitin-like protein 4
Protein Family:Small ubiquitin-related modifier
UniProt Gene Name:SUMO4 
UniProt Entry Name:SUMO4_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
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