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Anti-Survivin Antibody (CAB4838)

SKU:
CAB4838
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
API4
EPR-1
Research Area:
Cell Death
  • Cell Death Antibodies 2 Anti-Survivin Antibody CAB4838
  • Cell Death Antibodies 2 Anti-Survivin Antibody CAB4838
€139 - €419
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Description

Product Name:Survivin Rabbit mAb
Product Code:CAB4838
Size:20uL, 50uL, 100uL
Synonyms:API4, EPR-1
Applications:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Survivin
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse spleen, Mouse thymus, Rat testis
Immunogen:A synthesized peptide derived from human Survivin
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:332
Uniprot:O15392
Cellular Location:Chromosome, Cytoplasm, Midbody, Nucleus, centromere, cytoskeleton, kinetochore, spindle
Calculated MW:16kDa
Observed MW:18KDa
UniProt Protein Function:Survivin: an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described.
UniProt Protein Details:

Protein type:Apoptosis

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: centriole; nuclear chromosome; microtubule; spindle microtubule; cytoplasmic microtubule; cytoplasm; spindle; midbody; interphase microtubule organizing center; nucleus; cytosol; chromosome, pericentric region

Molecular Function:tubulin binding; identical protein binding; protein homodimerization activity; zinc ion binding; microtubule binding; metal ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; protein binding; enzyme binding; protein heterodimerization activity; chaperone binding; cofactor binding; cysteine protease inhibitor activity; Ran GTPase binding; cobalt ion binding

Biological Process: mitosis; transcription, DNA-dependent; spindle checkpoint; establishment of chromosome localization; regulation of signal transduction; protein ubiquitination; cytokinesis; negative regulation of caspase activity; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; chromosome segregation; protein complex localization; cell division; positive regulation of cell proliferation; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; positive regulation of exit from mitosis

NCBI Summary:This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
UniProt Code:O15392
NCBI GenInfo Identifier:380865472
NCBI Gene ID:332
NCBI Accession:O15392.3
UniProt Secondary Accession:O15392,Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2 Q9P2W8, A2SUH6, B2R4R1,
UniProt Related Accession:O15392
Molecular Weight:8,490 Da
NCBI Full Name:Baculoviral IAP repeat-containing protein 5
NCBI Synonym Full Names:baculoviral IAP repeat containing 5
NCBI Official Symbol:BIRC5  
NCBI Official Synonym Symbols:API4; EPR-1  
NCBI Protein Information:baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin variant 3 alpha; apoptosis inhibitor survivin
UniProt Protein Name:Baculoviral IAP repeat-containing protein 5
UniProt Synonym Protein Names:Apoptosis inhibitor 4; Apoptosis inhibitor survivin
Protein Family:Baculoviral IAP repeat-containing protein
UniProt Gene Name:BIRC5  
UniProt Entry Name:BIRC5_HUMAN

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