Anti-KMT1B / SUV39H2 Antibody (CAB3705)

Product Name:	KMT1B / SUV39H2 Rabbit mAb
Product Code:	CAB3705
Size:	20uL, 50uL, 100uL
Synonyms:	KMT1B
Applications:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human KMT1B / SUV39H2

Applications:	WB
Recommended Dilutions:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	HeLa, PC-3

Immunogen:	A synthesized peptide derived from human KMT1B / SUV39H2
Purification Method:	Affinity purification
Storage:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	79723
Uniprot:	Q9H5I1
Calculated MW:	47kDa
Observed MW:	47KDa

UniProt Protein Function:	SUV39H2: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation Chromosomal Location of Human Ortholog: 10p13 Cellular Component: nucleoplasm; nuclear heterochromatin; chromatin; chromosome, pericentric region Molecular Function:protein binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K9 specific); chromatin binding Biological Process: chromatin remodeling; chromatin assembly or disassembly; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; rhythmic process; negative regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; male meiosis; cell differentiation
UniProt Code:	Q9H5I1
NCBI GenInfo Identifier:	25091325
NCBI Gene ID:	79723
NCBI Accession:	Q9H5I1.2
UniProt Secondary Accession:	Q9H5I1,Q5JSS4, Q5JSS5, Q6I9Y3, Q8ND06, D3DRT4,
UniProt Related Accession:	Q9H5I1
Molecular Weight:	410
NCBI Full Name:	Histone-lysine N-methyltransferase SUV39H2
NCBI Synonym Full Names:	suppressor of variegation 3-9 homolog 2 (Drosophila)
NCBI Official Symbol:	SUV39H2
NCBI Official Synonym Symbols:	KMT1B
NCBI Protein Information:	histone-lysine N-methyltransferase SUV39H2; H3-K9-HMTase 2; su(var)3-9 homolog 2; lysine N-methyltransferase 1B; histone H3-K9 methyltransferase 2
UniProt Protein Name:	Histone-lysine N-methyltransferase SUV39H2
UniProt Synonym Protein Names:	Histone H3-K9 methyltransferase 2; H3-K9-HMTase 2; Lysine N-methyltransferase 1B; Suppressor of variegation 3-9 homolog 2; Su(var)3-9 homolog 2
Protein Family:	Histone-lysine N-methyltransferase
UniProt Gene Name:	SUV39H2
UniProt Entry Name:	SUV92_HUMAN