T10B9.1A-31 Antibody is a research-grade biosimilar monoclonal antibody targeting T cell receptor alpha chain constant. It is a mouse IgG2b, kappa antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
T cell receptor alpha chain constant (TRAC) is a ~15 kDa protein. Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.
Product Name:
T10B9.1A-31 Antibody
SKU:
GXBS00543
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
T cell receptor alpha chain constant
Isotype:
IgG2b, kappa
Host Species:
Mouse
Reactivity:
Human
Applications:
ELISA, FCM, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
MEDI-500, T10B9, T10B9.1A-31
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4.
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
![Purified Anti-Human CD326 Antibody [rMOC-31] (AGEL5277)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/271281/690861/purified-anti-human-cd326-antibody-rmoc-31-agel5277__29133.1774501166.jpg?c=2 "Purified Anti-Human CD326 Antibody [rMOC-31] (AGEL5277)")
![Purified Anti-Human CD154 Antibody [24-31] (AGEL5028)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/271032/691178/purified-anti-human-cd154-antibody-24-31-agel5028__72150.1774502138.jpg?c=2 "Purified Anti-Human CD154 Antibody [24-31] (AGEL5028)")
