Description
TAFV GP1 Recombinant Protein (N-His)
TAFV GP1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ile33-Gly495, with an N-terminal His tag. Predicted molecular weight: 52.82 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Envelope glycoprotein (GP1) is a ~74 kDa protein. GP1 is responsible for binding to the receptor(s) on target cells. For research use only.
Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection). Binding to the macrophage specific lectin CLEC10A also seems to enhance virus infectivity.
| Product Name: | TAFV GP1 Recombinant Protein (N-His) |
| SKU: | GXRP07131 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Cote d'Ivoire Ebola virus |
| Synonyms: | Envelope glycoprotein, GP, GP1, |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ile33-Gly495 |
| Calculated MW: | 52.82 kDa |
| UniProt: | Q05320 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
