Tagmokitug Antibody is a research-grade biosimilar monoclonal antibody targeting CD198. It is a human IgG1, kappa antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry and functional assays. Endotoxin: < 10 EU/mg. Purity: >95% as determined by SDS-PAGE. For research use only.
C-C chemokine receptor type 8 is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage.
Product Name:
Tagmokitug Antibody
SKU:
GXBS02689
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
CD198/CCR8
Isotype:
IgG1, lambda2
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FACS, Functional assay
Synonyms:
CAS: 3024486-14-1
Purity:
>95% as determined by SDS-PAGE
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
