Tau 4R Antibody is a rabbit polyclonal antibody directed against Tau 4R, offered by Assay Genie for research applications. Reported applications include WB and DB. Reported reactivity: Human, Mouse and Rat. Purified by Protein A.
Tau 4R spliceoforms, generated through alternative splicing of MAPT exon 10, play a central role in the molecular pathogenesis of several primary tauopathies, including frontotemporal lobar degeneration (FTLD), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP). An imbalance in the physiological 3R:4R tau ratio disrupts microtubule stabilization and accelerates the formation of pathogenic tau aggregates, underscoring the importance of spliceoform homeostasis in maintaining neuronal integrity. Elevated expression of 4R tau, particularly in disease contexts such as VCP-related FTD, has been shown to drive neurodegeneration by promoting tau hyperphosphorylation, endolysosomal dysfunction, and apoptosis, demonstrating a direct causal link between increased 4R tau burden and neuronal vulnerability. Moreover, emerging evidence emphasizes that tau isoform imbalance is itself a pathogenic driver across multiple neurodegenerative diseases, with 4R-dominant states contributing to disease-specific patterns of tau aggregation and clinical progression, further highlighting the need for mechanistic and therapeutic focus on 4R spliceoform regulation. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
Tau 4R Antibody
Product SKU:
STPA00092
Size:
100 µg
Target:
Tau 4R
Host Species:
Rabbit
Antibody Type:
Polyclonal
Research Areas:
Neuroscience, Neurodegeneration, Parkinson's Disease, ALS Disease, Alzheimer's Disease
Buffer:
PBS pH 7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Conjugated antibodies should be stored according to the product label. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, DB
Purification:
Protein A Purified
Concentration:
1 mg/mL
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000); optimal dilutions for assays should be determined by the user.
Specificity:
Detects Tau 4R spliceoforms
Guarantee:
12 months from date of dispatch
Immunogen:
Tau peptide
Immunogen Species:
Human
Accession Number:
P10636
Gene ID:
4137
Swiss-Prot:
P10636
Cellular Localization:
Localized to the Plasma membrane.
Tissue Specificity:
Cytoplasmic expression mainly in CNS, peripheral nerves and renal tubules.
1. Buchholz, S., & Zempel, H. (2024). The six brain-specific TAU isoforms and their role in Alzheimer’s disease and related neurodegenerative dementia syndromes. Alzheimer’s Association Journals. DOI: 10.1002/alz.13784 2. Hung, C., & Patani, R. (2024). Elevated 4R tau contributes to endolysosomal dysfunction and neurodegeneration in VCP-related frontotemporal dementia. Brain, 147(3), 970–979. DOI: 10.1093/brain/awad370 3. Zhang, X., Wang, J., Zhang, Z., & Ye, K. (2024). Tau in neurodegenerative diseases: Molecular mechanisms, biomarkers, and therapeutic strategies. Translational Neurodegeneration, 13(40). DOI: 10.1186/s40035-024-00429-6
