Tau Antibody (pSer202/ pThr205) [AH36] is a rabbit recombinant monoclonal antibody directed against Tau Antibody (pSer202/ pThr205), offered by Assay Genie for research applications. Reported applications include WB, DB, ICC/IF, ELISA and IHC. Reported reactivity: Human and Mouse. Supplied as IgG, purified by Affinity.
Tau is a microtubule-associated protein that plays a critical role in stabilizing neuronal microtubules and maintaining axonal integrity. In healthy neurons, tau is tightly regulated; however, in neurodegenerative diseases such as Alzheimer’s disease (AD), tau becomes abnormally hyperphosphorylated, leading to the formation of neurofibrillary tangles (NFTs). Phosphorylation at serine 202 and threonine 205 (pSer202/pThr205) is a well-characterized early marker of pathological tau. This dual phosphorylation induces a conformational change in tau, promoting its detachment from microtubules and facilitating aggregation into insoluble fibrils. These aggregates disrupt neuronal function and are strongly correlated with cognitive decline in AD. The pSer202/pThr205 epitope is recognized by the widely used AT8 antibody, making it a critical biomarker for both research and diagnostic applications. Detection of this epitope is commonly used in histopathological studies and in the development of tau-targeted therapeutics. Given its specificity for early tau pathology, pSer202/pThr205 is a focal point in the study of tauopathies and a promising target for therapeutic intervention and biomarker development in neurodegenerative disease research. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Tau, TAU, TAU_HUMAN, MAPT, MAPTL, Microtubule-associated protein tau, Microtubule associated protein tau, Microtubule associated protein tau isoform 4, Neurofibrillary tangle protein, Paired helical filament tau, Paired helical filament-tau, PHF tau, PHF-tau, DDPAC, FTDP 17, G protein beta1/gamma2 subunit interacting factor 1, MSTD, Mtapt, MTBT1, MTBT2, PPND, PPP1R103, Protein phosphatase 1 regulatory subunit 103, RNPTAU, AI413597, AW045860, FLJ31424, MGC134287, MGC138549, MGC156665
References:
1. www.alz.org/alzheimers-dementia/facts-figures 2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907) 3. Matsumoto, G. et al. (2018). Int J Mol Sci. 19, 1497. 4. Depres, C. et al. (2017). PNAS 114(34):9080-9085.
