Tau Antibody is a rabbit polyclonal antibody directed against Tau, offered by Assay Genie for research applications. Reported applications include WB. Reported reactivity: Human, Mouse and Rat. Purified by Protein A.
Tau is a microtubule-associated protein encoded by the MAPT gene and plays a vital role in stabilizing neuronal microtubules. In Alzheimer’s disease (AD) and related tauopathies, tau undergoes pathological modifications that lead to its aggregation into paired helical filaments (PHFs), forming neurofibrillary tangles—a hallmark of AD. A truncated tau fragment comprising residues 297–391, known as Tau dGAE, represents a minimal core region capable of self-assembling into PHF-like fibrils in vitro without the need for cofactors or templates. This 95-amino acid segment has been identified in the core of PHFs extracted from AD brain tissue and forms filaments that closely mimic those observed in human pathology. Tau dGAE is a powerful model for studying the molecular mechanisms of tau aggregation, seeding, and propagation. Its ability to recapitulate key structural features of pathological tau makes it an essential tool for developing aggregation inhibitors, imaging agents, and immunotherapies targeting tau fibrils. By isolating the aggregation-prone core of tau, researchers can dissect the structural transitions and biochemical interactions that drive neurodegeneration, making Tau dGAE a critical focus in Alzheimer’s disease research and therapeutic development. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Tau, MAPT, Microtubule-associated protein tau, Microtubule associated protein tau, Microtubule associated protein tau isoform 4, TAU_HUMAN, TAU, MAPTL, MTBT1, MTBT2, RNPTAU, PHF-tau, PHF tau, Paired helical filament tau, Paired helical filament-tau, Neurofibrillary tangle protein, DDPAC, FTDP 17, MSTD, PPND, PPP1R103, Protein phosphatase 1 regulatory subunit 103, G protein beta1/gamma2 subunit interacting factor 1, AI413597, AW045860, FLJ31424, MGC134287, MGC138549, MGC156663, dGAE tau fibril, Truncated Tau Fragment (AA297-391), 95-amino acid tau protein fragment, Truncated Tau Protein
References:
1. www.alz.org/alzheimers-dementia/facts-figures 2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907) 3. Al-Hilaly, Y.K. et al. Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking. J. Mol. Biol. 429(23):3650-3665 (2017)
