TEAD3 Antibody (PACO05190)
- SKU:
- PACO05190
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | TEAD3 Antibody (PACO05190) |
| Antibody SKU: | PACO05190 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from the Internal region of human TEF-5. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | TEAD3; TEAD5; TEF5; Transcriptional enhancer factor TEF-5; DTEF-1; TEA domain family member 3; TEAD-3 |
| UniProt Protein Function: | TEAD3: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p21.2 Cellular Component: nucleoplasm Molecular Function:protein binding; transcription factor activity Biological Process: asymmetric neuroblast division; female pregnancy; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99594 |
| NCBI GenInfo Identifier: | 2501157 |
| NCBI Gene ID: | 7005 |
| NCBI Accession: | Q99594.2 |
| UniProt Secondary Accession: | Q99594,O95910, Q5BJG7, Q8N6Y4, |
| UniProt Related Accession: | Q99594 |
| Molecular Weight: | 48,676 Da |
| NCBI Full Name: | Transcriptional enhancer factor TEF-5 |
| NCBI Synonym Full Names: | TEA domain transcription factor 3 |
| NCBI Official Symbol: | TEAD3 |
| NCBI Official Synonym Symbols: | TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3 |
| NCBI Protein Information: | transcriptional enhancer factor TEF-5 |
| UniProt Protein Name: | Transcriptional enhancer factor TEF-5 |
| UniProt Synonym Protein Names: | DTEF-1; TEA domain family member 3; TEAD-3 |
| Protein Family: | Transcriptional enhancer factor |
| UniProt Gene Name: | TEAD3 |
| UniProt Entry Name: | TEAD3_HUMAN |
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