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TEK Rabbit Polyclonal Antibody (CAB0743)

SKU:
CAB0743
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:TEK Rabbit Polyclonal Antibody
SKU:CAB0743
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 500-750 of human TEK (NP_000450.2).
Sequence:EIVT LNYL EPRT EYEL CVQL VRRG EGGE GHPG PVRR FTTA SIGL PPPR GLNL LPKS QTTL NLTW QPIF PSSE DDFY VEVE RRSV QKSD QQNI KVPG NLTS VLLN NLHP REQY VVRA RVNT KAQG EWSE DLTA WTLS DILP PQPE NIKI SNIT HSSA VISW TILD GYSI SSIT IRYK VQGK NEDQ HVDV KIKN ATIT QYQL KGLE PETA YQVD IFAE NNIG SSNP AFSH ELVT LPES QAPA DLGG GKML LIA
Tested Applications:WB ELISA
Recommended Dilution:WB,1:100 - 1:500
Synonyms:TIE2; VMCM; GLC3E; TIE-2; VMCM1; CD202B; TEK
Positive Sample:HUVEC
Conjugate:Unconjugated
Cellular Localization:Cell junction, Cell membrane, Cytoplasm, Secreted, Single-pass type I membrane protein, cytoskeleton, focal adhesion.
Calculated MW:126kDa
Observed MW:150kDa

This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Purification Method:Affinity purification
Gene ID:7010
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from HUVEC cells, using TEK Rabbit pAb (CAB0743) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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