Description
Teprotumumab ELISA Kit
The Teprotumumab ELISA Kit (SKU: GXEL00090) is a quantitative sandwich ELISA designed for the accurate quantitative detection of Teprotumumab across Plasma, Serum. With a working range of 62.5 ng/mL - 4, 000 ng/mL, the kit combines a simple protocol with dependable colorimetric read-out for confident quantification.
Teprotumumab is a human IgG1 monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF1R) that is used in the therapy of Graves ophthalmopathy (thyroid eye disease). Graves disease is an autoimmune disease associated with autoantibodies, hyperthyroidism and a distinctive form of eye disease marked by ocular inflammation and proptosis causing eye pain, dryness, redness, and swelling which if severe can cause diplopia (double-vision) and loss of vision. Graves ophthalmopathy is associated with autoantibodies to thyrotropin and hypertrophy of ocular fibroblasts which overexpress the IGF1 receptor. Teprotumumab causes inhibition of IGF1 binding to its receptor and preventing cell activation. IGF1 is a potent modulator of cell growth and inhibitor of programmed cell death, acting via the PI3K-AKT-mTOR pathway. The inhibition of IGF1 signaling decreases fibroblast proliferation and hypertrophy.
Backed by Assay Genie quality control and technical support, this Teprotumumab ELISA Kit is an ideal tool for laboratories studying Teprotumumab. Order the Teprotumumab ELISA Kit from Assay Genie for dependable performance.
| Product Name: | Teprotumumab ELISA Kit |
| SKU: | GXEL00090 |
| Accession: | P08069 |
| Alternative Names: | RO4858696-000, 1036734-93-6 |
| Assay Type: | Quantitative |
| Detection Method: | Colorimetric |
| Range: | 62.5 ng/mL - 4, 000 ng/mL |
| Sample Type: | Plasma, Serum |
| Storage: | 2-8°C. See Storage & Stability for details. |
| Note: | For Research Use Only. Not for diagnostic procedures. |
| Parameter | Specification |
|---|---|
| Assay Type | Quantitative |
| Detection Method | Colorimetric |
| Detection Range | 62.5 ng/mL - 4, 000 ng/mL |
| Recovery | 80-120% |
| Sample Types | Plasma, Serum |
When the kit was stored at the recommended temperature for 6 months, the signal intensity decreased by less than 20%. For unopened kits, if you want to prolong the storage time, please store the Standard, Detection A, Detection B and Microplate at - 20°C, the rest reagents should be store at 4°C.
Store the kit at 2-8°C on receipt. Avoid repeated freeze-thaw cycles.
