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Anti-Timp1 Antibody (MACO0526)

SKU:
MACO0526
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Mouse
Isotype:
IgG1
Applications:
ELISA
IHC
Antibody Type:
Monoclonal Antibody
Conjugation:
Unconjugated
€379
Frequently bought together:

Description

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Product Name:Anti-Timp1 Antibody
Product Sku:MACO0526
Size:50ug
Host Species:Mouse
Tested Applications:ELISA, IHC
Recommended Dilutions:IHC:1:50-1:500
Species Reactivity:Rat
Immunogen:Recombinant Rat Timp1
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%,Protein G purified
Clonality:Monoclonal
Isotype:IgG1
Conjugate:Non-conjugated
Background:Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
Synonyms:Timp-1
Product ImageImmunohistochemistry of paraffin-embedded Rat prostate cancer using MACO0526 at dilution of 1:100.
UniProt Protein Function:Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
NCBI Summary:acts as an inhibitor of metalloprotease activity; may play a role in vascular tissue remodeling [RGD, Feb 2006]
UniProt Code:P30120
NCBI GenInfo Identifier:1174697
NCBI Gene ID:116510
NCBI Accession:P30120.2
UniProt Secondary Accession:P30120,P70533, Q53YM7,
UniProt Related Accession:P30120
Molecular Weight:23,794 Da
NCBI Full Name:Metalloproteinase inhibitor 1
NCBI Synonym Full Names:TIMP metallopeptidase inhibitor 1
NCBI Official Symbol:Timp1  
NCBI Official Synonym Symbols:Timp; TIMP-1  
NCBI Protein Information:metalloproteinase inhibitor 1; tissue inhibitor of metallopeptidase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinases 1
UniProt Protein Name:Metalloproteinase inhibitor 1
UniProt Synonym Protein Names:Tissue inhibitor of metalloproteinases 1; TIMP-1
Protein Family:Metalloproteinase inhibitor
UniProt Gene Name:Timp1  
UniProt Entry Name:TIMP1_RAT

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