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TIMP1 Rabbit Polyclonal Antibody (CAB1389)

SKU:
CAB1389
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 1 Anti-TIMP1 Antibody CAB1389
  • Immunology Antibodies 1 Anti-TIMP1 Antibody CAB1389
  • Immunology Antibodies 1 Anti-TIMP1 Antibody CAB1389
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:TIMP1 Rabbit Polyclonal Antibody
SKU:CAB1389
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 128-207 of human TIMP1 (NP_003245.1).
Sequence:WNSL SLAQ RRGF TKTY TVGC EECT VFPC LSIP CKLQ SGTH CLWT DQLL QGSE KGFQ SRHL ACLP REPG LCTW QSLR SQIA
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:1000 - 1:5000 IF/ICC,1:50 - 1:200
Synonyms:EPA; EPO; HCI; CLGI; TIMP; TIMP-1; TIMP1
Positive Sample:HeLa,Rat uterus
Conjugate:Unconjugated
Cellular Localization:Secreted.
Calculated MW:23kDa
Observed MW:28kDa

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Purification Method:Affinity purification
Gene ID:7076
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using TIMP1 Rabbit pAb (CAB1389) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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