The TPH2 Antibody (CAB14520) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.TPH2 is a critical enzyme in the production of serotonin, a neurotransmitter that plays a key role in mood regulation and emotional well-being. Dysregulation of TPH2 has been implicated in various psychiatric disorders, including depression, anxiety, and schizophrenia.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
TPH2 Antibody
SKU:
CAB14520
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
NTPH, ADHD7, TPH2
Positive Sample:
NTERA-2, Mouse brain
Cellular Localization:
Cytosol, Neuron Projection.
Calculated MW:
56kDa
Observed MW:
52-56kDa
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
Purification Method
Affinity purification
Gene ID
121278
RRID
AB_2761396
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates, using TPH2 Rabbit pAb (CAB14520) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
