VAK-694 Antibody is a research-grade biosimilar monoclonal antibody. It is a humanized IgG1 antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays, in vivo research and Western blot. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Interleukin-4 (IL4) is a ~17 kDa protein. Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1. Also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.
Product Name:
VAK-694 Antibody
SKU:
GXBS00530
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
Binetrakin
Isotype:
IgG1
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FACS, Functional assay, Research in vivo, WB
Expression Host:
Mammalian cells
Synonyms:
VAK-694, NVP-VAK-694
Recommended Dilutions:
WB: 1:500-1:2000
Biological Activity:
VAK-694 binds to IL-4, reduces allergen-specific IL-4 producing cell numbers [1]. VAK-694 exerts immunomodulatory effects on TH2 memory cells [2].
Purity:
>95% purity as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
