| UniProt Protein Function: | VAV2: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed in most tissues. |
| UniProt Protein Details: | Protein type:GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 9q34.2 Cellular Component: cytosol Molecular Function:guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity Biological Process: ephrin receptor signaling pathway; platelet activation; positive regulation of apoptosis; regulation of blood coagulation; regulation of cell size; regulation of gene expression; regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | P52735 |
| NCBI GenInfo Identifier: | 212287930 |
| NCBI Gene ID: | 7410 |
| NCBI Accession: | P52735.2 |
| UniProt Secondary Accession: | P52735,Q5SYV3, Q5SYV4, Q5SYV5, Q6N012, Q6PIJ9, Q6Q317 A2RUM4, A8MQ12, B6ZDF5, |
| UniProt Related Accession: | P52735 |
| Molecular Weight: | 97,032 Da |
| NCBI Full Name: | Guanine nucleotide exchange factor VAV2 |
| NCBI Synonym Full Names: | vav guanine nucleotide exchange factor 2 |
| NCBI Official Symbol: | VAV2Â Â |
| NCBI Official Synonym Symbols: | VAV-2Â Â |
| NCBI Protein Information: | guanine nucleotide exchange factor VAV2 |
| UniProt Protein Name: | Guanine nucleotide exchange factor VAV2 |
| Protein Family: | Guanine nucleotide exchange factor |
| UniProt Gene Name: | VAV2Â Â |
