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Immunology Antibodies 3 Anti-ZAP70 Antibody CAB9536
Key Features

ZAP70 Rabbit Monoclonal Antibody (CAB9536)

Datasheet MSDS
SKU CAB9536
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human, Mouse
Host Species Rabbit
Synonyms SRK, STD, TZK, STCD, IMD48, ADMIO2, ZAP-70, ZAP70
Research Use Immunology
$173 - $603

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Description

system_update_altDatasheetsystem_update_altMSDS

ZAP70 Monoclonal Antibody (CAB9536)

The ZAP70 Monoclonal Antibody (CAB9536) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced using rabbit monoclonal technology, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blotting and immunohistochemistry applications.ZAP70 is a critical component of the T-cell receptor signaling pathway, playing a crucial role in activating and modulating T-cell responses. Dysregulation of ZAP70 has been linked to various immune-related disorders, including autoimmune diseases and certain types of leukemia.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:ZAP70 Monoclonal Antibody
SKU:CAB9536
Size:20μL, 100μL
Reactivity:Human, Mouse
Clone Number:ARC51229
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:SDVW SYGV TMWE ALSY GQKP YKKM KGPE VMAF IEQG KRME CPPE CPPE LYAL MSDC WIYK WEDR PDFL TVEQ RMRA CYYS LASK VEGP PGST QKAE AACA
Tested Applications:WB ELISA
Recommended Dilution:
WB1:1000 - 1:10000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:SRK, STD, TZK, STCD, IMD48, ADMIO2, ZAP-70, ZAP70
Positive Sample:Jurkat, MOLT-4, Mouse thymus
Cellular Localization:Cell Membrane, Cytoplasm, Peripheral Membrane Protein.
Calculated MW:70kDa
Observed MW:73kDa

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID7535
RRIDAB_2863716
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using ZAP70 Rabbit mAb (CAB9536) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Product ImageWestern blot analysis of lysates from Mouse thymus, using ZAP70 Rabbit mAb (CAB9536) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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